Synthesis and LC-MS/MS analysis of desmosine-CH2, a potential internal standard for the degraded elastin biomarker desmosineElectronic supplementary information (ESI) available: 1H and 13C NMR spectra for synthetic compounds. See DOI: 10.1039/c4ob01438c

Desmosine-CH 2 , an analog of the elastic tissue degradation biomarker desmosine, can be regarded as a potential internal standard for precise quantification of desmosines by LC-MS/MS. In this study, the chemical synthesis of desmosine-CH 2 was completed in 22% overall yield in five steps. The LC-MS...

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Main Authors: Murakami, Yuko, Suzuki, Rina, Yanuma, Hiroto, He, Jiangtao, Ma, Shuren, Turino, Gerard M, Lin, Yong Y, Usuki, Toyonobu
Format: Article
Language:English
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Summary:Desmosine-CH 2 , an analog of the elastic tissue degradation biomarker desmosine, can be regarded as a potential internal standard for precise quantification of desmosines by LC-MS/MS. In this study, the chemical synthesis of desmosine-CH 2 was completed in 22% overall yield in five steps. The LC-MS/MS analysis of desmosine-CH 2 was also achieved. Chemical synthesis and LC-MS/MS analysis of desmosine-CH 2 , a potential internal standard for the degraded elastin biomarker desmosine, are achieved.
ISSN:1477-0520
1477-0539
DOI:10.1039/c4ob01438c