Regioselective ruthenium catalysed H-D exchange using D2O as the deuterium sourceElectronic supplementary information (ESI) available: Experimental details and characterization data for all new compounds and all products. See DOI: 10.1039/c4ob01798f

An efficient and convenient ruthenium catalysed method for a regiospecific H/D exchange using D 2 O is described. Organic moieties such as pyridine, oxazole, imidazole, pyrazole, ester, ketone and carboxylic acid have been found effective directing groups in this transformation. In addition, the deu...

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Main Authors: Piola, Lorenzo, Fernández-Salas, José A, Manzini, Simone, Nolan, Steven P
Format: Article
Language:English
Online Access:Get full text
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Summary:An efficient and convenient ruthenium catalysed method for a regiospecific H/D exchange using D 2 O is described. Organic moieties such as pyridine, oxazole, imidazole, pyrazole, ester, ketone and carboxylic acid have been found effective directing groups in this transformation. In addition, the deuteration of the enantiopure ( S )-Ketoprofen leads to the incorporation of three deuterium atoms with retention of molecular chirality. An efficient and convenient ruthenium catalysed method for a regiospecific H/D exchange using D 2 O is described.
ISSN:1477-0520
1477-0539
DOI:10.1039/c4ob01798f