C-N and C-P bond formation via cross dehydrative coupling reaction: an efficient synthesis of novel 3,4-dihydroquinazolinesElectronic supplementary information (ESI) available: Detailed experimental procedures, 1H, 13C and 31P NMR copy of all new compounds and crystallographic details (CCDC and CIF) of compounds 5i, 5p and 7e. CCDC 996992, 996993 and 996994. For ESI and crystallographic data in CIF or other electronic format see DOI: 10.1039/c4ra10203g

• Main Authors: Saidulu, G, Arun Kumar, R, Anitha, T, Srinivasulu, A, Sridhar, B, Liu, Shiuh Tzung, Rajender Reddy, K
• Format: Article
• Language: English
• ISSN: 2046-2069
• DOI: 10.1039/c4ra10203g

A new methodology has been developed to construct C-N and C-P bonds through direct coupling of C-OH and N-H/P-H bonds via dehydrative cross coupling reaction. Furthermore, this protocol offers an efficient and straightforward way to access a biologically important nitrogen-heterocycle, namely, 3,4-dihydroquinazoline utilizing either an inexpensive iron catalyst or under metal-free conditions. A new method to construct C-N and C-P bonds through dehydrative cross coupling of C-OH and N-H/P-H bonds is reported under metal (Fe) or metal-free conditions and efficiently applied for the synthesis of 3,4-dihydroquinazoline derivatives.