Deep eutectic solvent based on choline chloride and malonic acid as an efficient and reusable catalytic system for one-pot synthesis of functionalized pyrrolesElectronic supplementary information (ESI) available. CCDC 1008451. For ESI and crystallographic data in CIF or other electronic format see DOI: 10.1039/c4ra13577f

A deep eutectic solvent (DES) based on choline chloride and malonic acid was prepared easily with high purity at a low cost. It has been applied as a dual catalyst and reaction medium for the synthesis of functionalized pyrroles by a one-pot, four-component reaction of amines, aldehydes, 1,3-dicarbo...

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Main Authors: Hu, Hai-Chuan, Liu, Yu-Heng, Li, Bao-Le, Cui, Zhen-Shui, Zhang, Zhan-Hui
Format: Article
Language:English
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Summary:A deep eutectic solvent (DES) based on choline chloride and malonic acid was prepared easily with high purity at a low cost. It has been applied as a dual catalyst and reaction medium for the synthesis of functionalized pyrroles by a one-pot, four-component reaction of amines, aldehydes, 1,3-dicarbonyl compounds and nitromethane. This green solvent could be recycled and reused three times without loss of its efficiency. Deep eutectic solvent (DES) based on choline chloride and malonic acid was applied as catalyst and reaction medium for synthesis of pyrroles by one-pot, four-component reaction of amines, aldehydes, 1,3-dicarbonyl compounds and nitromethane.
ISSN:2046-2069
DOI:10.1039/c4ra13577f