Synthesis of Au yolk/LDH shell nanoparticles as anticancer vehiclesElectronic supplementary information (ESI) available. See DOI: 10.1039/c4ra14585b

In this paper, anticancer drug methotrexate (MTX) is applied as a coupling agent to fabricate Au@SiO 2 core-shell structures for the first time. Then, a novel kind of Au yolk/LDH shell nanoparticles is obtained by using Au@SiO 2 as the template. Finally, the in vitro cytotoxicity is examined and the...

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Bibliographic Details
Main Authors: Huo, Xiaolei, Dai, Chaofan, Li, Shuping, Li, Xiaodong
Format: Article
Language:English
Online Access:Get full text
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Summary:In this paper, anticancer drug methotrexate (MTX) is applied as a coupling agent to fabricate Au@SiO 2 core-shell structures for the first time. Then, a novel kind of Au yolk/LDH shell nanoparticles is obtained by using Au@SiO 2 as the template. Finally, the in vitro cytotoxicity is examined and the result indicates that the yolk/shell nanovehicles loaded with MTX exhibit superior anticancer efficacy, compared to the free drug. MTX serves as both the anticancer targeting drug loaded on LDH sheets and effective surface-coupling agent for SiO 2 coating.
ISSN:2046-2069
DOI:10.1039/c4ra14585b