Collision cross section calibrants for negative ion mode traveling wave ion mobility-mass spectrometryElectronic supplementary information (ESI) available: Document containing an alternative TWIM CCS calibration strategy and TWIM CCS values of polylactic acid and polyaspartic acid. See DOI: 10.1039/c5an00946d

Unlike traditional drift-tube ion mobility-mass spectrometry, traveling-wave ion mobility-mass spectrometry typically requires calibration in order to generate collision cross section (CCS) values. Although this has received a significant amount of attention for positive-ion mode analysis, little at...

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Main Authors: Forsythe, Jay G, Petrov, Anton S, Walker, Chelsea A, Allen, Samuel J, Pellissier, Jarrod S, Bush, Matthew F, Hud, Nicholas V, Fernández, Facundo M
Format: Article
Language:English
Online Access:Get full text
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Summary:Unlike traditional drift-tube ion mobility-mass spectrometry, traveling-wave ion mobility-mass spectrometry typically requires calibration in order to generate collision cross section (CCS) values. Although this has received a significant amount of attention for positive-ion mode analysis, little attention has been paid for CCS calibration in negative ion mode. Here, we provide drift-tube CCS values for [M − H] − ions of two calibrant series, polyalanine and polymalic acid, and evaluate both types of calibrants in terms of the accuracy and precision of the traveling-wave ion mobility CCS values that they produce. Introduction of a novel negative mode calibrant and evaluation of calibration strategies for TWIM CCS determination.
ISSN:0003-2654
1364-5528
DOI:10.1039/c5an00946d