Receptor selective ruthenium-somatostatin photosensitizer for cancer targeted photodynamic applicationsElectronic supplementary information (ESI) available: Synthesis protocols, characterization and cell studies. See DOI: 10.1039/c5cc03473f

The efficient conjugation of a ruthenium complex and the peptide hormone somatostatin is presented. The resultant biohybrid offers valuable features for photodynamic therapy such as remarkable cellular selectivity, rapid cell uptake by receptor-mediated endocytosis, efficient generation of 1 O 2 upo...

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Main Authors: Wang, Tao, Zabarska, Natalia, Wu, Yuzhou, Lamla, Markus, Fischer, Stephan, Monczak, Katharina, Ng, David Y. W, Rau, Sven, Weil, Tanja
Format: Article
Language:English
Online Access:Get full text
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Summary:The efficient conjugation of a ruthenium complex and the peptide hormone somatostatin is presented. The resultant biohybrid offers valuable features for photodynamic therapy such as remarkable cellular selectivity, rapid cell uptake by receptor-mediated endocytosis, efficient generation of 1 O 2 upon irradiation, potent phototoxicity as well as low cytotoxicity in the "off"-state. The efficient conjugation of a ruthenium complex and the peptide hormone somatostatin is presented. The resultant biohybrid offers many valuable features for photodynamic therapy.
ISSN:1359-7345
1364-548X
DOI:10.1039/c5cc03473f