Iron-catalyzed direct α-arylation of ethers with azolesElectronic supplementary information (ESI) available. See DOI: 10.1039/c5cc05005g

The direct α-arylation of cyclic and acyclic ethers with azoles has been achieved, which features a novel iron-catalyzed cross-dehydrogenative coupling (CDC) process. This practical oxidative method allowed the efficient C2-alkylation of a variety of (benzo)azoles constituting straightforward access...

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Bibliographic Details
Main Authors: Correa, Arkaitz, Fiser, Béla, Gómez-Bengoa, Enrique
Format: Article
Language:English
Online Access:Get full text
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Summary:The direct α-arylation of cyclic and acyclic ethers with azoles has been achieved, which features a novel iron-catalyzed cross-dehydrogenative coupling (CDC) process. This practical oxidative method allowed the efficient C2-alkylation of a variety of (benzo)azoles constituting straightforward access to heterocycles of utmost medicinal significance and highlighting the convenient use of feedstock substrates and iron catalysts. A preliminary mechanism supported by DFT calculations is discussed as well. The direct α-arylation of cyclic and acyclic ethers with azoles has been achieved, which features a novel iron-catalyzed cross-dehydrogenative coupling (CDC) process.
ISSN:1359-7345
1364-548X
DOI:10.1039/c5cc05005g