Copper-mediated three-component synthesis of 3-cyanoimidazo[1,2-a]pyridinesElectronic supplementary information (ESI) available. See DOI: 10.1039/c5cc05821j

A copper-mediated three-component approach towards the synthesis of 3-cyanoimidazo[1,2- a ]pyridines from 2-aminopyridines, acetophenones and benzyl cyanide was developed. This cascade reaction proceeds through a copper-mediated oxidative release of cyanide from benzyl cyanide, a copper-mediated Ort...

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Main Authors: Wen, Qiaodong, Lu, Ping, Wang, Yanguang
Format: Article
Language:English
Online Access:Get full text
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Summary:A copper-mediated three-component approach towards the synthesis of 3-cyanoimidazo[1,2- a ]pyridines from 2-aminopyridines, acetophenones and benzyl cyanide was developed. This cascade reaction proceeds through a copper-mediated oxidative release of cyanide from benzyl cyanide, a copper-mediated Ortoleva-King reaction, and a copper-catalyzed cyanation. A copper-mediated three-component approach towards the synthesis of 3-cyanoimidazo[1,2- a ]pyridines from 2-aminopyridines, acetophenones and benzyl cyanide was developed. This cascade reaction proceeds through a copper-mediated oxidative release of cyanide from benzyl cyanide, a copper-mediated Ortoleva-King reaction, and a copper-catalyzed cyanation.
ISSN:1359-7345
1364-548X
DOI:10.1039/c5cc05821j