N-Substitution dependent stereoselectivity switch in palladium catalyzed hydroalkynylation of ynamides: a regio and stereoselective synthesis of ynenamidesThis communication is dedicated to Dr J. S. Yadav on the occasion of his 65th birthday.Electronic supplementary information (ESI) available. CCDC 1414222, 1414252, 1414290 and 1414552. For ESI and crystallographic data in CIF or other electronic format see DOI: 10.1039/c5cc06251a

A highly general palladium catalysed regioselective hydroalkynylation of ynamides for versatile enamide building blocks with an alkyne tether is achieved with an N -substitution dependent stereoselectivity switch under very mild reaction conditions. A palladium catalysed regioselective hydroalkynyla...

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Main Authors: Dwivedi, Vikas, Hari Babu, Madala, Kant, Ruchir, Sridhar Reddy, Maddi
Format: Article
Language:English
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Summary:A highly general palladium catalysed regioselective hydroalkynylation of ynamides for versatile enamide building blocks with an alkyne tether is achieved with an N -substitution dependent stereoselectivity switch under very mild reaction conditions. A palladium catalysed regioselective hydroalkynylation of ynamides for ynenamides is achieved with an N -substitution dependent stereoselectivity switch.
ISSN:1359-7345
1364-548X
DOI:10.1039/c5cc06251a