Self-assembly of the anti-fungal polyene amphotericin B into giant helically-twisted nanotapesElectronic supplementary information (ESI) available: Methods, mass spectroscopy and NMR data, cryo-TEM images and SAXS data. See DOI: 10.1039/c5cc08224b

The amphiphilic polyene amphotericin B, a powerful treatment for systemic fungal infections, is shown to exhibit a critical aggregation concentration, and to form giant helically-twisted nanostructures via self-assembly in basic aqueous solution. Amphotericin B self-assembles into giant nanotapes wi...

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Bibliographic Details
Main Authors: Hamley, Ian William, Kirkham, Steven, Kowalczyk, Radoslaw M, Castelletto, Valeria, Reza, Mehedi, Ruokolainen, Janne
Format: Article
Language:English
Online Access:Get full text
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Summary:The amphiphilic polyene amphotericin B, a powerful treatment for systemic fungal infections, is shown to exhibit a critical aggregation concentration, and to form giant helically-twisted nanostructures via self-assembly in basic aqueous solution. Amphotericin B self-assembles into giant nanotapes with an internal filament structure in pH 12 aqueous solution.
ISSN:1359-7345
1364-548X
DOI:10.1039/c5cc08224b