A new class of Ru() polyazine agents with potential for photodynamic therapy

Appending anthracene units to [(bpy) 2 Ru(dpp)] 2+ results in Ru( ii ) agents that exhibit dynamic photoreactivity towards DNA and protein. [(Anthbpy)(bpy)Ru(dpp)] 2+ and [(Anthbpy) 2 Ru(dpp)] 2+ are the first metal-organic Ru( ii ) agent with dpp ligands shown to photomodify DNA in the presence or...

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Bibliographic Details
Published in:Chemical communications (Cambridge, England) England), 2016-02, Vol.52 (13), p.275-278
Main Authors: Padilla, Roberto, Rodriguez-Corrales, José A, Donohoe, Lauren E, Winkel, Brenda S. J, Brewer, Karen J
Format: Article
Language:English
Subjects:
Binding
Deoxyribonucleic acid
Dynamics
Ligands
Oxygen
Photochemotherapy
Photodynamic therapy
Photosensitizing Agents - chemistry
Photosensitizing Agents - therapeutic use
Polyazines
Proteins
Ruthenium Compounds - chemistry
Ruthenium Compounds - therapeutic use
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Summary:Appending anthracene units to [(bpy) 2 Ru(dpp)] 2+ results in Ru( ii ) agents that exhibit dynamic photoreactivity towards DNA and protein. [(Anthbpy)(bpy)Ru(dpp)] 2+ and [(Anthbpy) 2 Ru(dpp)] 2+ are the first metal-organic Ru( ii ) agent with dpp ligands shown to photomodify DNA in the presence or absence of oxygen, while also binding protein in an oxygen-dependent manner. Appending anthracene units to [(bpy) 2 Ru(dpp)] 2+ results in Ru( ii ) agents that exhibit dynamic photoreactivity towards DNA and protein.
ISSN:1359-7345
1364-548X
DOI:10.1039/c5cc08682e