Review: in vitro microvessel models

A wide range of perfusable microvessel models have been developed, exploiting advances in microfabrication, microfluidics, biomaterials, stem cell technology, and tissue engineering. These models vary in complexity and physiological relevance, but provide a diverse tool kit for the study of vascular...

Full description

Saved in:
Bibliographic Details
Published in:Lab on a chip 2015-01, Vol.15 (22), p.4242-4255
Main Authors: Bogorad, Max I, DeStefano, Jackson, Karlsson, Johan, Wong, Andrew D, Gerecht, Sharon, Searson, Peter C
Format: Article
Language:English
Subjects:
Animals
Artificial organs
Biomaterials
Biomedical materials
Endothelium, Vascular - cytology
Humans
Microfluidic Analytical Techniques - instrumentation
Microfluidics
Models, Biological
State of the art
Stem cells
Surgical implants
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:A wide range of perfusable microvessel models have been developed, exploiting advances in microfabrication, microfluidics, biomaterials, stem cell technology, and tissue engineering. These models vary in complexity and physiological relevance, but provide a diverse tool kit for the study of vascular phenomena and methods to vascularize artificial organs. Here we review the state-of-the-art in perfusable microvessel models, summarizing the different fabrication methods and highlighting advantages and limitations. Perfusable microvessel models.
ISSN:1473-0197
1473-0189
1473-0189
DOI:10.1039/c5lc00832h