A benzotriazole-mediated route to protected marine-derived hetero-2,5-diketopiperazines containing prolineElectronic supplementary information (ESI) available: Experimental section. Copy of 1H NMR, 13C NMR, HRMS analysis data of the compounds. See DOI: 10.1039/c5ob00023h

A procedure for the cyclization of dipeptidoyl benzotriazolides containing proline derivatives promoted by triethylamine under MW activation is introduced. The reaction is general for a variety of dipeptidoyl benzotriazolides and represents a very practical and convenient method for the preparation...

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Main Authors: Nsengiyumva, Olivier, Hamedzadeh, Sadra, McDaniel, James, Macho, Jocelyn, Simpson, Grant, Panda, Siva S, Ha, Khanh, Lebedyeva, Iryna, Faidallah, Hassan M, AL-Mohammadi, Manal Metgen, Hall, C. Dennis, Katritzky, Alan R
Format: Article
Language:English
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Summary:A procedure for the cyclization of dipeptidoyl benzotriazolides containing proline derivatives promoted by triethylamine under MW activation is introduced. The reaction is general for a variety of dipeptidoyl benzotriazolides and represents a very practical and convenient method for the preparation of Pro- or Hyp-derived 2,5-diketopiperazines (2,5-DKPs) and bis-DKPs with a disulfide linker. This method can be used for the construction of 2,5-DKP compound libraries and for the synthesis of natural products with diketopiperazine cores. Dipeptidoyl benzotriazolides containing proline were cyclized by triethylamine into 2,5-diketopiperazines.
ISSN:1477-0520
1477-0539
DOI:10.1039/c5ob00023h