DNA-capped FeO/SiO magnetic mesoporous silica nanoparticles for potential controlled drug release and hyperthermia

We proposed a strategy to construct DNA-capped Fe 3 O 4 /SiO 2 magnetic mesoporous silica (MMS) nanoparticles for potential temperature controlled drug release and magnetic hyperthermia. Drug release behavior, magnetic heating capacity, in vitro cytotoxicity, and cell uptake of the MMS-based nanocar...

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Bibliographic Details
Published in:RSC advances 2015-02, Vol.5 (29), p.22365-22372
Main Authors: Zhu, Yufang, Tao, Cuilian
Format: Article
Language:English
Online Access:Get full text
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Summary:We proposed a strategy to construct DNA-capped Fe 3 O 4 /SiO 2 magnetic mesoporous silica (MMS) nanoparticles for potential temperature controlled drug release and magnetic hyperthermia. Drug release behavior, magnetic heating capacity, in vitro cytotoxicity, and cell uptake of the MMS-based nanocarriers were evaluated. The results showed that the DOX/MMS-NH 2 -dsDNA complexes could release DOX fast at 50 °C, but very slow at 37 °C. Also, MMS-based nanocarriers could efficiently generate heat upon exposure to an alternating magnetic field due to the superparamagnetic behavior. Furthermore, the MMS-NH 2 -dsDNA complexes could be effectively taken up by murine breast cancer 4T1 cells, and negligible cytotoxicity of the MMS-NH 2 -dsDNA complexes has been observed. Therefore, DNA-capped MMS nanoparticles had potential for cancer therapy with temperature controlled drug release and magnetic hyperthermia. DNA-capped Fe 3 O 4 /SiO 2 magnetic mesoporous silica (MMS) nanoparticles were developed for potential temperature controlled drug release and magnetic hyperthermia.
ISSN:2046-2069
DOI:10.1039/c5ra00701a