Ene-nucleic acids: a different paradigm to DNA chemistry

Acyclic prochiral nucleic acids such as FNA, UNA, GNA and cyclic chiral TNA are all considered as precursors of DNA and RNA in the chemical etiology of nucleic acids. The chemical reasoning would suggest that unsaturated precursors with constrained flexibility and selectivity based on cis / trans is...

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Bibliographic Details
Published in:RSC advances 2015-01, Vol.5 (118), p.97824-9783
Main Authors: Varada, Manojkumar, Erande, Namrata D, Kumar, Vaijayanti A
Format: Article
Language:English
Subjects:
Deoxyribonucleic acid
Flexibility
Forming
Links
Nucleic acids
Precursors
Ribonucleic acids
Unsaturated
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Summary:Acyclic prochiral nucleic acids such as FNA, UNA, GNA and cyclic chiral TNA are all considered as precursors of DNA and RNA in the chemical etiology of nucleic acids. The chemical reasoning would suggest that unsaturated precursors with constrained flexibility and selectivity based on cis / trans isomers could be the missing link between the prochiral-acyclic and chiral-cyclic structures mentioned above. We find that ene-nucleic acids derived from an isoprenoid skeleton possess requisite flexibility and rigidity while forming stable duplex structures with complementary DNA and RNA. The chemical reasoning would suggest that Ene-nucleic acid precursors with constrained flexibility and selectivity could be the missing link between the prochiral-acyclic and chiral-cyclic structures.
ISSN:2046-2069
2046-2069
DOI:10.1039/c5ra15673d