Exploiting novel process windows for the synthesis of meso-substituted porphyrins under continuous flow conditionsElectronic supplementary information (ESI) available: Copy of UV-Vis, 1H and 13C NMR spectra, LC/MS data of all compounds. See DOI: 10.1039/c5ra16962c

Porphyrin synthesis by classical methods frequently involves the use of high temperatures, toxic and dangerous reagents yielding the product in very low amounts and with poor scalability. Herein, we have studied the synthesis of meso -substituted porphyrins under continuous flow conditions, thus dem...

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Bibliographic Details
Main Authors: Momo, Patrícia B, Bellete, Barbara S, Brocksom, Timothy J, de Souza, Rodrigo O. M. A, de Oliveira, Kleber T
Format: Article
Language:English
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Summary:Porphyrin synthesis by classical methods frequently involves the use of high temperatures, toxic and dangerous reagents yielding the product in very low amounts and with poor scalability. Herein, we have studied the synthesis of meso -substituted porphyrins under continuous flow conditions, thus demonstrating scale-up for the porphyrin synthesis in a safe, cost-competitive, highly pure, reproducible and robust manner. Porphyrin synthesis by classical methods frequently involves harsh conditions yielding products with poor scalability. Herein, a continuous flow approach is described, thus demonstrating a scaled-up procedure in a safe and highly pure manner.
ISSN:2046-2069
DOI:10.1039/c5ra16962c