Construction of pyrazolo[5,1-]isoindol-8(3)-one derivatives phosphine-catalyzed cyclization of electron-deficient alkynes and -amino substituted phthalimide

A novel method for the synthesis of diversely functionalized pyrazolo[5,1- a ]isoindol-8(3 aH )-ones is developed via phosphine-catalyzed tandem Michael addition/intramolecular Morita-Baylis-Hillman reaction of electron-deficient alkynes and N -amino substituted phthalimide. This cyclization is oper...

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Published in:RSC advances 2015-12, Vol.6 (2), p.1395-142
Main Authors: Zhou, Qing-Fa, Ge, Fei-Fei, Chen, Qing-Qing, Lu, Tao
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Summary:A novel method for the synthesis of diversely functionalized pyrazolo[5,1- a ]isoindol-8(3 aH )-ones is developed via phosphine-catalyzed tandem Michael addition/intramolecular Morita-Baylis-Hillman reaction of electron-deficient alkynes and N -amino substituted phthalimide. This cyclization is operationally simple under metal-free reaction conditions. A novel method for the synthesis of diversely functionalized pyrazolo[5,1- a ]isoindol-8(3 aH )-ones is developed via phosphine-catalyzed reaction of electron-deficient alkynes and N -amino substituted phthalimide.
ISSN:2046-2069
DOI:10.1039/c5ra17267e