Dual T1/T2 MRI contrast agent based on hybrid SPION@coordination polymer nanoparticlesElectronic supplementary information (ESI) available: Synthetic and experimental procedures, SEM and TEM images, FT-IR, UV-Vis, Mössbauer and EDX spectra. See DOI: 10.1039/c5ra17661a

We report a novel hybrid T 1 / T 2 dual MRI contrast agent by the encapsulation of SPIONs ( T 2 contrast agent) into an iron-based coordination polymer with T 1 -weighted signal. This new hybrid material presents improved relaxometry and low cytotoxicity, which make it suitable for its use as contra...

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Main Authors: Borges, M, Yu, S, Laromaine, A, Roig, A, Suárez-García, S, Lorenzo, J, Ruiz-Molina, D, Novio, F
Format: Article
Language:English
Online Access:Get full text
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Summary:We report a novel hybrid T 1 / T 2 dual MRI contrast agent by the encapsulation of SPIONs ( T 2 contrast agent) into an iron-based coordination polymer with T 1 -weighted signal. This new hybrid material presents improved relaxometry and low cytotoxicity, which make it suitable for its use as contrast agent for MRI. A novel dual T 1 / T 2 1 H-MRI contrast agent based on the encapsulation of super-paramagnetic iron oxide nanoparticles (SPIONs) with an iron coordination polymer is proposed.
ISSN:2046-2069
DOI:10.1039/c5ra17661a