Triterpenes from the fruits of with acetylcholinesterase and Aβ-aggregation inhibitory activities

A lupane-type triterpene ( 1 ) featuring a rare 2-hemiacetal moiety in its A ring and aromatic ester derivatives ( 2-6 ) were isolated from the fruits of R. laevigata and evaluated to possess acetylcholinesterase and Aβ-aggregation inhibitory activities. Their structures were determined by multi-spe...

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Published in:RSC advances 2016-01, Vol.6 (3), p.2431-2435
Main Authors: Gao, Pin-Yi, Wang, Meng, Liu, Xue-Gui, Gao, Yi-Xing, Li, Jia-Luo, Zhang, Zhen-Xue, Lin, Hou-Wen, Song, Shao-Jiang
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Summary:A lupane-type triterpene ( 1 ) featuring a rare 2-hemiacetal moiety in its A ring and aromatic ester derivatives ( 2-6 ) were isolated from the fruits of R. laevigata and evaluated to possess acetylcholinesterase and Aβ-aggregation inhibitory activities. Their structures were determined by multi-spectroscopic methods, chemosynthesis and CD analysis. A lupane-type triterpene ( 1 ) featuring a rare 2-hemiacetal moiety and aromatic ester derivatives ( 2-6 ) were isolated from R. laevigata and evaluated to possess acetylcholinesterase and Aβ-aggregation inhibitory activities.
ISSN:2046-2069
DOI:10.1039/c5ra21590k