An update of biocatalytic selective acylation and deacylation of monosaccharides

Partially acylated monosaccharides (PAMs) exhibit diverse and interesting applications but due to their polyhydroxylated nature, their synthesis requires regio- and stereoselective reactions. These features are provided by biocatalytic processes and in particular by hydrolases, which offer mild cond...

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Bibliographic Details
Published in:RSC advances 2016-01, Vol.6 (2), p.16358-16386
Main Authors: Iribarren, Adolfo M, Iglesias, Luis E
Format: Article
Language:English
Subjects:
Acylation
Conjugates
Monosaccharides
Strategy
Synthesis (chemistry)
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Summary:Partially acylated monosaccharides (PAMs) exhibit diverse and interesting applications but due to their polyhydroxylated nature, their synthesis requires regio- and stereoselective reactions. These features are provided by biocatalytic processes and in particular by hydrolases, which offer mild conditions and selective routes for the preparation of PAMs. Since this strategy has been extensively explored, the aim of the present review is to update research on enzymatic selective acylation and deacylation of monosaccharides, focusing on enzymatic preparation of synthetic useful PAMs and drug-monosaccharide conjugates involving PAMs. PAMs synthesis requires highly selective reactions, provided by hydrolases. This review updates research on enzymatic acylation and deacylation of monosaccharides, focusing on synthetic useful PAMs and drug-monosaccharide conjugates involving PAMs.
ISSN:2046-2069
2046-2069
DOI:10.1039/c5ra23453k