Revealing the trehalose mediated inhibition of protein aggregation through lysozyme-silver nanoparticle interactionElectronic supplementary information (ESI) available. See DOI: 10.1039/c5sm01896j

We propose a facile and robust carbohydrate-mediated method for the prevention of nanoparticle induced denaturation and aggregation of proteins. Using label-free plasmon-enhanced Raman spectroscopy measurements, the mechanistic principles of trehalose stabilization in a model protein-nanoparticle sy...

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Bibliographic Details
Main Authors: Siddhanta, Soumik, Barman, Ishan, Narayana, Chandrabhas
Format: Article
Language:English
Online Access:Get full text
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Summary:We propose a facile and robust carbohydrate-mediated method for the prevention of nanoparticle induced denaturation and aggregation of proteins. Using label-free plasmon-enhanced Raman spectroscopy measurements, the mechanistic principles of trehalose stabilization in a model protein-nanoparticle system are elucidated for the first time, facilitating its further application in diagnostic and therapeutic nanoplex development. We propose a facile and robust carbohydrate-mediated method for the prevention of nanoparticle induced denaturation and aggregation of proteins.
ISSN:1744-683X
1744-6848
DOI:10.1039/c5sm01896j