Antineoplastic busulfan encapsulated in a metal organic framework nanocarrier: first results

Nanoparticles of a mesoporous iron( iii ) trimesate MIL-100 nanocarrier encapsulating high amounts of the challenging antineoplastic busulfan were administered to rats and compared with the commercial Busilvex®. Large differences in serum concentration of both busulfan and trimesate revealed the gre...

Full description

Saved in:
Bibliographic Details
Published in:Journal of materials chemistry. B, Materials for biology and medicine Materials for biology and medicine, 2016-01, Vol.4 (4), p.585-588
Main Authors: Simon-Yarza, M. T, Baati, T, Paci, A, Lesueur, L. L, Seck, A, Chiper, M, Gref, R, Serre, C, Couvreur, P, Horcajada, P
Format: Article
Language:
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Nanoparticles of a mesoporous iron( iii ) trimesate MIL-100 nanocarrier encapsulating high amounts of the challenging antineoplastic busulfan were administered to rats and compared with the commercial Busilvex®. Large differences in serum concentration of both busulfan and trimesate revealed the great impact of drug encapsulation both on the drug and on nanoparticle pharmacokinetics during the first 24 h of administration. Nanoparticles of a mesoporous iron( iii ) trimesate MIL-100 nanocarrier encapsulating high amounts of the challenging antineoplastic busulfan were administered to rats and compared with the commercial Busilvex®.
ISSN:2050-750X
2050-7518
DOI:10.1039/c5tb02084k