Catalytic enantio- and diastereoselective Mannich reaction of -substituted isocyanoacetates and ketimines

The highly diastereo- and enantioselective Mannich addition/cyclisation reaction of -substituted isocyanoacetate ester pronucleophiles and (hetero)aryl and alkyl methyl ketone-derived ketimines using a silver acetate and a cinchona-derived amino phosphine binary catalyst system is reported. The high...

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Bibliographic Details
Published in:Chemical communications (Cambridge, England) England), 2016-08, Vol.52 (7), p.1632-1635
Main Authors: de la Campa, Raquel, Gammack Yamagata, Adam D, Ortn, Irene, Franchino, Allegra, Thompson, Amber L, Odell, Barbara, Dixon, Darren J
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Summary:The highly diastereo- and enantioselective Mannich addition/cyclisation reaction of -substituted isocyanoacetate ester pronucleophiles and (hetero)aryl and alkyl methyl ketone-derived ketimines using a silver acetate and a cinchona-derived amino phosphine binary catalyst system is reported. The highly diastereo- and enantioselective Mannich reaction/cyclisation of -substituted isocyanoacetates and ketimines catalysed by silver acetate and a cinchona-derived amino phosphine is reported.
ISSN:1359-7345
1364-548X
DOI:10.1039/c6cc04132a