Aminoglycoside-based novel probes for bacterial diagnostic and therapeutic applicationsElectronic supplementary information (ESI) available. See DOI: 10.1039/c6cc08292k

Specific detection of pathogens has long been recognized as a vital strategy in the control of infectious diseases. Two novel theranostic neomycin analogs exhibit efficient targeting, labelling and killing of broad spectrum bacteria while not damaging macrophage-like cells. Furthermore, lipidated pr...

Full description

Saved in:
Bibliographic Details
Main Authors: Zhang, Qingyang, Wang, Qinghua, Xu, Shengnan, Zuo, Limin, You, Xuefu, Hu, Hai-Yu
Format: Article
Language:English
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Specific detection of pathogens has long been recognized as a vital strategy in the control of infectious diseases. Two novel theranostic neomycin analogs exhibit efficient targeting, labelling and killing of broad spectrum bacteria while not damaging macrophage-like cells. Furthermore, lipidated probe 2 clearly showed antibacterial activity against methicillin-resistant S. aureus . A theranostic agent for broad spectrum pathogenic bacterial imaging and MRSA growth inhibition was developed.
ISSN:1359-7345
1364-548X
DOI:10.1039/c6cc08292k