Easy access to triazolinedione-endcapped peptides for chemical ligationElectronic supplementary information (ESI) available: Experimental procedures, characterization data, UPLC and NMR of new compounds. See DOI: 10.1039/c6cc08683g

An efficient and easy route towards triazolinedione (TAD) endcapped peptides is described, in which a TAD-precursor was coupled to N-terminal amines on a solid support. Modified peptides readily reacted with diene end-functionalized poly( -caprolactone) of different molecular weights. The ligation p...

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Bibliographic Details
Main Authors: Wilke, P, Kunde, T, Chattopadhyay, S, ten Brummelhuis, N, Du Prez, F. E, Börner, H. G
Format: Article
Language:English
Online Access:Get full text
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Summary:An efficient and easy route towards triazolinedione (TAD) endcapped peptides is described, in which a TAD-precursor was coupled to N-terminal amines on a solid support. Modified peptides readily reacted with diene end-functionalized poly( -caprolactone) of different molecular weights. The ligation proved to be orthogonal to a variety of functional groups present in natural amino acids. A triazolinedione-precursor is directly built up from N-terminal peptide amines on resin, enabling a versatile route towards peptide-polymer conjugates.
ISSN:1359-7345
1364-548X
DOI:10.1039/c6cc08683g