One-pot synthesis of alternating peptides exploiting a new polymerization technique based on Ugi's 4CC reactionElectronic supplementary information (ESI) available: Experimental procedures and characterization data for all reactions and products, including 1H NMR, 13C NMR, IR, and DOSY spectra and DLS profiles. See DOI: 10.1039/c6cc09379e

We developed a one-pot synthetic technique for alternating peptides. Central to this technique is a new, catalyst-free polymerization based on Ugi's 4CC reaction. The treatment of imines with the ambident molecules bearing both an isocyanide and a carboxylic acid afforded alternating peptides....

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Bibliographic Details
Main Authors: Koyama, Yasuhito, Gudeangadi, Prashant G
Format: Article
Language:English
Online Access:Get full text
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Summary:We developed a one-pot synthetic technique for alternating peptides. Central to this technique is a new, catalyst-free polymerization based on Ugi's 4CC reaction. The treatment of imines with the ambident molecules bearing both an isocyanide and a carboxylic acid afforded alternating peptides. A catalyst-free, one-pot synthetic technique for alternating peptides was developed on the basis of Ugi's 4 component condensation reaction.
ISSN:1359-7345
1364-548X
DOI:10.1039/c6cc09379e