Accessing alternative reaction pathways of the intermolecular condensation between homo-propargyl alcohols and terminal alkynes through divergent gold catalysisElectronic supplementary information (ESI) available: Experimental procedures and spectroscopic data of new compounds. CCDC 1521359-1521361. For ESI and crystallographic data in CIF or other electronic format see DOI: 10.1039/c6cc09794d

An intermolecular condensation of alkynols and terminal alkynes is reported. Using IPrAuNTf 2 , an efficient Au-catalyzed cyclization-alkynylation strategy furnishes (2-arylalkynyl) cyclic ethers in moderate to excellent yields (up to 94%). This strategy is extended to the synthesis of functionalize...

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Main Authors: Smith, Courtney A, Motika, Stephen E, Wojtas, Lukasz, Shi, Xiaodong
Format: Article
Language:English
Online Access:Get full text
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Summary:An intermolecular condensation of alkynols and terminal alkynes is reported. Using IPrAuNTf 2 , an efficient Au-catalyzed cyclization-alkynylation strategy furnishes (2-arylalkynyl) cyclic ethers in moderate to excellent yields (up to 94%). This strategy is extended to the synthesis of functionalized 2,3-dihydrooxepines via the sequential Au-catalyzed ring expansion of the cyclic ether substrates. An intermolecular condensation of alkynols and terminal alkynes is reported.
ISSN:1359-7345
1364-548X
DOI:10.1039/c6cc09794d