An acid-cleavable phthalocyanine tetramer as an activatable photosensitiser for photodynamic therapy

An acetal-linked self-quenched zinc( ii ) phthalocyanine tetramer has been prepared. In an acidic environment in phosphate buffered saline or inside tumour cells, the phthalocyanine units of the tetramer are separated thereby restoring the fluorescence emission and singlet oxygen production. This re...

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Bibliographic Details
Published in:Dalton transactions : an international journal of inorganic chemistry 2016-08, Vol.45 (33), p.1321-1324
Main Authors: Chow, Sun Y. S, Lo, Pui-Chi, Ng, Dennis K. P
Format: Article
Language:English
Subjects:
Buffers
Cell Line, Tumor
Cell Survival - drug effects
Emission
Fluorescence
Fluorescent Dyes - administration & dosage
Fluorescent Dyes - chemistry
Humans
Indoles - administration & dosage
Indoles - chemistry
Phosphates
Photochemotherapy
Photodynamic therapy
Photosensitizing Agents - administration & dosage
Photosensitizing Agents - chemistry
Saline
Singlet oxygen
Singlet Oxygen - chemistry
Tumors
Zinc - administration & dosage
Zinc - chemistry
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Summary:An acetal-linked self-quenched zinc( ii ) phthalocyanine tetramer has been prepared. In an acidic environment in phosphate buffered saline or inside tumour cells, the phthalocyanine units of the tetramer are separated thereby restoring the fluorescence emission and singlet oxygen production. This response enables this compound to serve as a promising activatable photosensitiser for photodynamic therapy. A novel self-quenched phthalocyanine tetramer has been prepared which can be activated in acidic environments, resulting in enhanced fluorescence emission and singlet oxygen production.
ISSN:1477-9226
1477-9234
DOI:10.1039/c6dt02283a