Synthesis of symmetrical pyridines by iron-catalyzed cyclization of ketoxime acetates and aldehydesElectronic supplementary information (ESI) available: Detailed experimental procedures and spectral data and copies of NMR spectra for all products. See DOI: 10.1039/c6gc03137d

A novel and facile iron-catalyzed cyclization of ketoxime acetates and aldehydes for the green synthesis of substituted pyridines has been developed. In the presence of a FeCl 3 catalyst, this reaction exhibited a good functional group tolerance to produce 2,4,6-triarylsubstituted symmetrical pyridi...

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Main Authors: Yi, YuKun, Zhao, Mi-Na, Ren, Zhi-Hui, Wang, Yao-Yu, Guan, Zheng-Hui
Format: Article
Language:English
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Summary:A novel and facile iron-catalyzed cyclization of ketoxime acetates and aldehydes for the green synthesis of substituted pyridines has been developed. In the presence of a FeCl 3 catalyst, this reaction exhibited a good functional group tolerance to produce 2,4,6-triarylsubstituted symmetrical pyridines in high yields in the absence of any additive. A gram-scale reaction sequence was performed to demonstrate the scaled-up applicability of this synthetic method. A facile iron-catalyzed cyclization of aldehydes with ketoxime acetates for the synthesis of multisubstituted symmetrical pyridines has been developed.
ISSN:1463-9262
1463-9270
DOI:10.1039/c6gc03137d