Synthesis, antioxidant and antitumoral activities of 5′-arylchalcogeno-3-aminothymidine (ACAT) derivativesThe authors declare no competing interests.Electronic supplementary information (ESI) available: Experimental procedures, NMR data and spectra, HRMS and a full description of the biological activities. See DOI: 10.1039/c6md00640j

This article presents the preparation and in vitro biological activities of new 5′-arylchalcogeno-3-aminothymidine derivatives as antioxidants (inhibition of lipid peroxidation, scavenging of the free radical 2,2-diphenylpicrylhydrazyl and demonstration of a thiol peroxidase-like activity) as well a...

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Main Authors: da Rosa, Raquel Mello, Piccoli, Bruna Candia, da Silva, Fernanda D'Avila, Dornelles, Luciano, Rocha, João B. T, Sonego, Mariana Souza, Begnini, Karine Rech, Collares, Tiago, Seixas, Fabiana K, Rodrigues, Oscar E. D
Format: Article
Language:English
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Summary:This article presents the preparation and in vitro biological activities of new 5′-arylchalcogeno-3-aminothymidine derivatives as antioxidants (inhibition of lipid peroxidation, scavenging of the free radical 2,2-diphenylpicrylhydrazyl and demonstration of a thiol peroxidase-like activity) as well as antitumoral agents against bladder carcinoma 5637. The chalcogeno-aminothymidines presented prominent activity in the tests for both biological properties, showing a direct relation with the chalcogenium atom. This article presents the preparation and in vitro biological activities of new 5′;-arylchalcogeno-3-aminothymidine derivatives as antioxidants as well as antitumoral agents against bladder carcinoma 5637.
ISSN:2040-2503
2040-2511
DOI:10.1039/c6md00640j