Loading…
Molecular diversity in several pyridyl based Cu(ii) complexes: biophysical interaction and redox triggered fluorescence switchElectronic supplementary information (ESI) available. CCDC of L1, C1a, C1b and C4 are 959012, 1059621, 1060660 and 855225 respectively. For ESI and crystallographic data in CIF or other electronic format see DOI: 10.1039/c6nj02381a
Variation of pyridyl based receptors around a Cu( ii ) center results in structural diversity allowing redox triggered Cu( ii )/Cu( i ) fluorescence switch for intracellular Cu( i ) imaging. Single crystal X-ray structures of 2-hydroxy-6-methylnicotinic acid ( L1 ), its mono nuclear Cu( ii ) complex...
Saved in:
| Main Authors: | , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Online Access: | Get full text |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| Summary: | Variation of pyridyl based receptors around a Cu(
ii
) center results in structural diversity allowing redox triggered Cu(
ii
)/Cu(
i
) fluorescence switch for intracellular Cu(
i
) imaging. Single crystal X-ray structures of 2-hydroxy-6-methylnicotinic acid (
L1
), its mono nuclear Cu(
ii
) complex,
viz.
[Cu(
L1
)
2
(H
2
O)(SO
4
)]·2H
2
O (
C1a
), polymeric Cu(
ii
) complex (
C1b
) and a dinuclear Cu(
ii
) complex of 2-(naphthalen-2-ylmethylsulfanyl)-nicotinic acid (
L4
),
viz.
[Cu
2
(
L4
)
4
(H
2
O)
2
]·1.12H
2
O (
C4
) with a Cu-Cu distance of 2.6028(7) Å are reported. Moreover,
C1a
interacts with calf thymus DNA, which is useful for disruption of normal DNA activity with plausible applications in biology (binding constant,
K
′ = 1.56 × 10
4
). Chemical or electrochemical reduction of
C1a
generates a fluorescent Cu(
i
) complex. The lowest detection limit of
L1
for Cu(
i
) is 50 μM. The association constant of
L1
for Cu
+
is 7.09 × 10
2
. Quenching constants of Cu(
ii
) for
L1
,
L2
,
L3
and
L4
are 4 × 10
5
, 4.2 × 10
6
, 8.9 × 10
5
and 4.4 × 10
6
, respectively. The magnetic behavior of
C1b
indicates a ferromagnetic one-dimensional solid.
A novel approach for detection of intra-cellular Cu
+
in
E. coli
and human blood cells is reported. Studies on several pyridyl based Cu(
ii
) complexes and interaction of ct DNA with one of them are carried out for plausible application in biology concerning disruption of normal DNA activity. |
|---|---|
| ISSN: | 1144-0546 1369-9261 |
| DOI: | 10.1039/c6nj02381a |