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Molecular diversity in several pyridyl based Cu(ii) complexes: biophysical interaction and redox triggered fluorescence switchElectronic supplementary information (ESI) available. CCDC of L1, C1a, C1b and C4 are 959012, 1059621, 1060660 and 855225 respectively. For ESI and crystallographic data in CIF or other electronic format see DOI: 10.1039/c6nj02381a

Variation of pyridyl based receptors around a Cu( ii ) center results in structural diversity allowing redox triggered Cu( ii )/Cu( i ) fluorescence switch for intracellular Cu( i ) imaging. Single crystal X-ray structures of 2-hydroxy-6-methylnicotinic acid ( L1 ), its mono nuclear Cu( ii ) complex...

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Main Authors: Adhikari, Sangita, Sahana, Animesh, Kumari, Babli, Ganguly, Durba, Das, Saurabh, Banerjee, Prajna Paramita, Banerjee, Gautam, Chattopadhyay, Ansuman, Fondo, Matilde, Matalobos, Jesús Sanmartín, Brandão, Paula, Félix, Vítor, Das, Debasis
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creator Adhikari, Sangita
Sahana, Animesh
Kumari, Babli
Ganguly, Durba
Das, Saurabh
Banerjee, Prajna Paramita
Banerjee, Gautam
Chattopadhyay, Ansuman
Fondo, Matilde
Matalobos, Jesús Sanmartín
Brandão, Paula
Félix, Vítor
Das, Debasis
description Variation of pyridyl based receptors around a Cu( ii ) center results in structural diversity allowing redox triggered Cu( ii )/Cu( i ) fluorescence switch for intracellular Cu( i ) imaging. Single crystal X-ray structures of 2-hydroxy-6-methylnicotinic acid ( L1 ), its mono nuclear Cu( ii ) complex, viz. [Cu( L1 ) 2 (H 2 O)(SO 4 )]·2H 2 O ( C1a ), polymeric Cu( ii ) complex ( C1b ) and a dinuclear Cu( ii ) complex of 2-(naphthalen-2-ylmethylsulfanyl)-nicotinic acid ( L4 ), viz. [Cu 2 ( L4 ) 4 (H 2 O) 2 ]·1.12H 2 O ( C4 ) with a Cu-Cu distance of 2.6028(7) Å are reported. Moreover, C1a interacts with calf thymus DNA, which is useful for disruption of normal DNA activity with plausible applications in biology (binding constant, K ′ = 1.56 × 10 4 ). Chemical or electrochemical reduction of C1a generates a fluorescent Cu( i ) complex. The lowest detection limit of L1 for Cu( i ) is 50 μM. The association constant of L1 for Cu + is 7.09 × 10 2 . Quenching constants of Cu( ii ) for L1 , L2 , L3 and L4 are 4 × 10 5 , 4.2 × 10 6 , 8.9 × 10 5 and 4.4 × 10 6 , respectively. The magnetic behavior of C1b indicates a ferromagnetic one-dimensional solid. A novel approach for detection of intra-cellular Cu + in E. coli and human blood cells is reported. Studies on several pyridyl based Cu( ii ) complexes and interaction of ct DNA with one of them are carried out for plausible application in biology concerning disruption of normal DNA activity.
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CCDC of L1, C1a, C1b and C4 are 959012, 1059621, 1060660 and 855225 respectively. For ESI and crystallographic data in CIF or other electronic format see DOI: 10.1039/c6nj02381a</title><source>Royal Society of Chemistry</source><creator>Adhikari, Sangita ; Sahana, Animesh ; Kumari, Babli ; Ganguly, Durba ; Das, Saurabh ; Banerjee, Prajna Paramita ; Banerjee, Gautam ; Chattopadhyay, Ansuman ; Fondo, Matilde ; Matalobos, Jesús Sanmartín ; Brandão, Paula ; Félix, Vítor ; Das, Debasis</creator><creatorcontrib>Adhikari, Sangita ; Sahana, Animesh ; Kumari, Babli ; Ganguly, Durba ; Das, Saurabh ; Banerjee, Prajna Paramita ; Banerjee, Gautam ; Chattopadhyay, Ansuman ; Fondo, Matilde ; Matalobos, Jesús Sanmartín ; Brandão, Paula ; Félix, Vítor ; Das, Debasis</creatorcontrib><description>Variation of pyridyl based receptors around a Cu( ii ) center results in structural diversity allowing redox triggered Cu( ii )/Cu( i ) fluorescence switch for intracellular Cu( i ) imaging. Single crystal X-ray structures of 2-hydroxy-6-methylnicotinic acid ( L1 ), its mono nuclear Cu( ii ) complex, viz. [Cu( L1 ) 2 (H 2 O)(SO 4 )]·2H 2 O ( C1a ), polymeric Cu( ii ) complex ( C1b ) and a dinuclear Cu( ii ) complex of 2-(naphthalen-2-ylmethylsulfanyl)-nicotinic acid ( L4 ), viz. [Cu 2 ( L4 ) 4 (H 2 O) 2 ]·1.12H 2 O ( C4 ) with a Cu-Cu distance of 2.6028(7) Å are reported. Moreover, C1a interacts with calf thymus DNA, which is useful for disruption of normal DNA activity with plausible applications in biology (binding constant, K ′ = 1.56 × 10 4 ). Chemical or electrochemical reduction of C1a generates a fluorescent Cu( i ) complex. The lowest detection limit of L1 for Cu( i ) is 50 μM. The association constant of L1 for Cu + is 7.09 × 10 2 . Quenching constants of Cu( ii ) for L1 , L2 , L3 and L4 are 4 × 10 5 , 4.2 × 10 6 , 8.9 × 10 5 and 4.4 × 10 6 , respectively. The magnetic behavior of C1b indicates a ferromagnetic one-dimensional solid. 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title Molecular diversity in several pyridyl based Cu(ii) complexes: biophysical interaction and redox triggered fluorescence switchElectronic supplementary information (ESI) available. CCDC of L1, C1a, C1b and C4 are 959012, 1059621, 1060660 and 855225 respectively. For ESI and crystallographic data in CIF or other electronic format see DOI: 10.1039/c6nj02381a
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