Coloured cornea replacements with anti-infective properties: expanding the safe use of silver nanoparticles in regenerative medicine

Despite the broad anti-microbial and anti-inflammatory properties of silver nanoparticles (AgNPs), their use in bioengineered corneal replacements or bandage contact lenses has been hindered due to their intense yellow coloration. In this communication, we report the development of a new strategy to...

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Bibliographic Details
Published in:Nanoscale 2016-01, Vol.8 (12), p.6484-6489
Main Authors: Alarcon, E. I, Vulesevic, B, Argawal, A, Ross, A, Bejjani, P, Podrebarac, J, Ravichandran, R, Phopase, J, Suuronen, E. J, Griffith, M
Format: Article
Language:English
Subjects:
Animals
Anti-Infective Agents - administration & dosage
Antiinfectives and antibacterials
Antimicrobial Cationic Peptides - chemistry
Biocompatible Materials
Collagen - chemistry
Collagens
Color
Colour
Cornea - surgery
Corneal Transplantation - instrumentation
Corneal Transplantation - methods
Hydrogels - chemistry
Implants
Interleukin-6 - metabolism
Lens, Crystalline - surgery
Materials Testing
Metal Nanoparticles - chemistry
Mice
Nanomedicine - methods
Nanoparticles
Regenerative Medicine - methods
Silver
Silver - chemistry
Strategy
Stress, Mechanical
Tensile Strength
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Summary:Despite the broad anti-microbial and anti-inflammatory properties of silver nanoparticles (AgNPs), their use in bioengineered corneal replacements or bandage contact lenses has been hindered due to their intense yellow coloration. In this communication, we report the development of a new strategy to pre-stabilize and incorporate AgNPs with different colours into collagen matrices for fabrication of corneal implants and lenses, and assessed their in vitro and in vivo activity. A methodology that allows safe incorporation of nanosilver in collagen hydrogels is reported in this work.
ISSN:2040-3364
2040-3372
2040-3372
DOI:10.1039/c6nr01339b