N-Heterocyclic carbene-triggered transition-metal-free synthesis of 2,3-disubstituted benzofuran derivatives

An NHC-triggered, transition-metal-free strategy for the efficient synthesis of 2,3-disubstituted benzofuran derivatives in moderate to excellent yields from aryl or alkyl aldehydes and o -quinone methides has been developed. This method features mild reaction conditions, operational simplicity, bro...

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Bibliographic Details
Published in:Organic & biomolecular chemistry 2016-07, Vol.14 (27), p.6463-6469
Main Authors: Xie, Yuanwei, Yu, Chenxia, Que, Yonglei, Li, Tuanjie, Wang, Yuhong, Lu, Yinan, Wang, Wenjing, Shen, Shide, Yao, Changsheng
Format: Article
Language:English
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Summary:An NHC-triggered, transition-metal-free strategy for the efficient synthesis of 2,3-disubstituted benzofuran derivatives in moderate to excellent yields from aryl or alkyl aldehydes and o -quinone methides has been developed. This method features mild reaction conditions, operational simplicity, broad substrate scope and convergent assembly. An NHC-triggered, transition-metal-free strategy for the efficient synthesis of 2,3-disubstituted benzofuran derivatives in moderate to excellent yields from aryl or alkyl aldehydes and o -quinone methides has been developed.
ISSN:1477-0520
1477-0539
DOI:10.1039/c6ob00363j