Biologically active γ-lactams: synthesis and natural sources

The γ-lactam moiety is present in a large number of natural and non-natural biologically active compounds. The range of biological activities covered by these compounds is very broad. Functionalized γ-lactams are thus of high interest and have great potential in medicinal chemistry. This review prov...

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Bibliographic Details
Published in:Organic & biomolecular chemistry 2016-11, Vol.14 (43), p.1134-1156
Main Authors: Caruano, J, Muccioli, G. G, Robiette, R
Format: Article
Language:English
Subjects:
Alkylation
Anti-Bacterial Agents - chemical synthesis
Anti-Bacterial Agents - chemistry
Biological Products - chemistry
Chemistry Techniques, Synthetic - methods
Cyclization
Lactams - chemical synthesis
Lactams - chemistry
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Summary:The γ-lactam moiety is present in a large number of natural and non-natural biologically active compounds. The range of biological activities covered by these compounds is very broad. Functionalized γ-lactams are thus of high interest and have great potential in medicinal chemistry. This review provides a description of the title compounds by focusing on their synthesis, natural sources and biological activities. This review surveys the different synthetic and natural sources of biologically active γ-lactam compounds.
ISSN:1477-0520
1477-0539
DOI:10.1039/c6ob01349j