Synthesis and antiproliferative activity of new tonantzitlolone-derived diterpene derivativesElectronic supplementary information (ESI) available. See DOI: 10.1039/c6ob01697a

The synthesis of the diterpene (+)-tonantzitlolone A and a series of derivatives is reported. The study includes the determination of their antiproliferative activities against selected cancer cell lines. The synthesis, determination of cytotoxic properties and phenotype visualisation during mitosis...

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Main Authors: Busch, Torsten, Dräger, Gerald, Kunst, Eike, Benson, Hannah, Sasse, Florenz, Siems, Karsten, Kirschning, Andreas
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Summary:The synthesis of the diterpene (+)-tonantzitlolone A and a series of derivatives is reported. The study includes the determination of their antiproliferative activities against selected cancer cell lines. The synthesis, determination of cytotoxic properties and phenotype visualisation during mitosis of tonantzitlolone A and 18 derivatives is reported.
ISSN:1477-0520
1477-0539
DOI:10.1039/c6ob01697a