Loading…

Photodynamic therapy with intralesional methylene blue and a 635 nm light-emitting diode lamp in hidradenitis suppurativa: a retrospective follow-up study in 7 patients and a review of the literature

Hidradenitis suppurativa is a chronic inflammatory skin disease which has an estimated prevalence of 1%. It is characterized by the formation of recurrent painful suppurative nodules and abscesses in the flexural areas of the body. It is believed that its pathogenesis involves an aberrant, genetical...

Full description

Saved in:
Bibliographic Details
Published in:Photochemical & photobiological sciences 2016-01, Vol.15 (8), p.12-128
Main Authors: Agut-Busquet, Eugènia, Romaní, Jorge, Gilaberte, Yolanda, García-Malinis, Ana, Ribera-Pibernat, Miquel, Luelmo, Jesús
Format: Article
Language:English
Subjects:
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
cited_by cdi_FETCH-LOGICAL-c526t-9464a2f77055ea9a5f9fcbdf4ec4df5468d7821b1e829046f1a54b46c1224cc93
cites cdi_FETCH-LOGICAL-c526t-9464a2f77055ea9a5f9fcbdf4ec4df5468d7821b1e829046f1a54b46c1224cc93
container_end_page 128
container_issue 8
container_start_page 12
container_title Photochemical & photobiological sciences
container_volume 15
creator Agut-Busquet, Eugènia
Romaní, Jorge
Gilaberte, Yolanda
García-Malinis, Ana
Ribera-Pibernat, Miquel
Luelmo, Jesús
description Hidradenitis suppurativa is a chronic inflammatory skin disease which has an estimated prevalence of 1%. It is characterized by the formation of recurrent painful suppurative nodules and abscesses in the flexural areas of the body. It is believed that its pathogenesis involves an aberrant, genetically-determined activation of innate immunity against the bacterial commensal flora of intertriginous areas. It has been found that the formation of antibiotic-resistant bacterial biofilms is a common finding in hidradenitis lesions. Photodynamic therapy with different compounds and light sources has demonstrated its efficacy in a number of infectious diseases such as nail mycosis and chronic periodontitis. We retrospectively report our experience in the treatment of hidradenitis with photodynamic therapy using intralesional methylene blue and a 635 nm light-emitting diode lamp in 7 patients. Two patients received one session whereas 5 patients received two sessions. At one month follow-up good response was achieved in 6 patients. After 6 months, 5 patients (71%) maintained remission of the disease in the treated area. In view of the results and literature review, we regard methylene blue as an ideal photosensitizer for photodynamic therapy in this disease. Hidradenitis suppurativa is a chronic inflammatory skin disease which has an estimated prevalence 1%. It is characterized by the formation of recurrent painful suppurative nodules and abscesses in the flexural areas of the body.
doi_str_mv 10.1039/c6pp00082g
format article
fullrecord <record><control><sourceid>proquest_rsc_p</sourceid><recordid>TN_cdi_rsc_primary_c6pp00082g</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1811880128</sourcerecordid><originalsourceid>FETCH-LOGICAL-c526t-9464a2f77055ea9a5f9fcbdf4ec4df5468d7821b1e829046f1a54b46c1224cc93</originalsourceid><addsrcrecordid>eNqNkU2P1DAMhisEYj_gwh2UIwIVkkzapntDKxaQVoIDSNyqNHGmWaVJSNId9Rfyt8hohoEDB0627MevLb9V9YzgNwRv-reyDQFjzOn2QXVOWMfqHvf04Slvvp9VFyndYUwa1naPqzPaMdI1LT-vfn6ZfPZqdWI2EuUJoggr2pk8IeNyFBaS8U5YNEOeVgsO0GgXQMIpJFC7aZCbkTXbKdcwm5yN2yJlvAJkxRyKBpqMikKBM9kklJYQliiyuRdXZT5Cjj4FkKUASHtr_a5eAkp5Uet-uEOhwOByOm6McG9gh7ze31oW53JwXiI8qR5pYRM8PcbL6tvN-6_XH-vbzx8-Xb-7rWVD21z3rGWC6q7DTQOiF43utRyVZiCZ0uU7XHWckpEApz1mrSaiYSNrJaGUSdlvLquXB90Q_Y8FUh5mkyRYKxz4JQ2EE8I5JpT_B4p5i1vakYK-OqCyvCNF0EOIZhZxHQge9h4Pfzwu8Iuj7jLOoE7ob1ML8PoApNJyW4jDnV9iMTH9W-75gY5JnrT-6v8C-ju-0A</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1808606271</pqid></control><display><type>article</type><title>Photodynamic therapy with intralesional methylene blue and a 635 nm light-emitting diode lamp in hidradenitis suppurativa: a retrospective follow-up study in 7 patients and a review of the literature</title><source>Springer Nature:Jisc Collections:Springer Nature Read and Publish 2023-2025: Springer Reading List</source><creator>Agut-Busquet, Eugènia ; Romaní, Jorge ; Gilaberte, Yolanda ; García-Malinis, Ana ; Ribera-Pibernat, Miquel ; Luelmo, Jesús</creator><creatorcontrib>Agut-Busquet, Eugènia ; Romaní, Jorge ; Gilaberte, Yolanda ; García-Malinis, Ana ; Ribera-Pibernat, Miquel ; Luelmo, Jesús</creatorcontrib><description>Hidradenitis suppurativa is a chronic inflammatory skin disease which has an estimated prevalence of 1%. It is characterized by the formation of recurrent painful suppurative nodules and abscesses in the flexural areas of the body. It is believed that its pathogenesis involves an aberrant, genetically-determined activation of innate immunity against the bacterial commensal flora of intertriginous areas. It has been found that the formation of antibiotic-resistant bacterial biofilms is a common finding in hidradenitis lesions. Photodynamic therapy with different compounds and light sources has demonstrated its efficacy in a number of infectious diseases such as nail mycosis and chronic periodontitis. We retrospectively report our experience in the treatment of hidradenitis with photodynamic therapy using intralesional methylene blue and a 635 nm light-emitting diode lamp in 7 patients. Two patients received one session whereas 5 patients received two sessions. At one month follow-up good response was achieved in 6 patients. After 6 months, 5 patients (71%) maintained remission of the disease in the treated area. In view of the results and literature review, we regard methylene blue as an ideal photosensitizer for photodynamic therapy in this disease. Hidradenitis suppurativa is a chronic inflammatory skin disease which has an estimated prevalence 1%. It is characterized by the formation of recurrent painful suppurative nodules and abscesses in the flexural areas of the body.</description><identifier>ISSN: 1474-905X</identifier><identifier>EISSN: 1474-9092</identifier><identifier>DOI: 10.1039/c6pp00082g</identifier><identifier>PMID: 27417568</identifier><language>eng</language><publisher>Cham: Springer International Publishing</publisher><subject>Adult ; Aminolevulinic Acid - therapeutic use ; Anti-Bacterial Agents - therapeutic use ; Biochemistry ; Biomaterials ; Chemistry ; Female ; Follow-Up Studies ; Hidradenitis Suppurativa - diagnostic imaging ; Hidradenitis Suppurativa - drug therapy ; Humans ; Light ; Longitudinal Studies ; Male ; Methylene Blue - therapeutic use ; Middle Aged ; Photochemotherapy ; Photosensitizing Agents - therapeutic use ; Physical Chemistry ; Plant Sciences ; Retrospective Studies ; Treatment Outcome ; Ultrasonography ; Young Adult</subject><ispartof>Photochemical &amp; photobiological sciences, 2016-01, Vol.15 (8), p.12-128</ispartof><rights>The Royal Society of Chemistry and Owner Societies 2016</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c526t-9464a2f77055ea9a5f9fcbdf4ec4df5468d7821b1e829046f1a54b46c1224cc93</citedby><cites>FETCH-LOGICAL-c526t-9464a2f77055ea9a5f9fcbdf4ec4df5468d7821b1e829046f1a54b46c1224cc93</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27417568$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Agut-Busquet, Eugènia</creatorcontrib><creatorcontrib>Romaní, Jorge</creatorcontrib><creatorcontrib>Gilaberte, Yolanda</creatorcontrib><creatorcontrib>García-Malinis, Ana</creatorcontrib><creatorcontrib>Ribera-Pibernat, Miquel</creatorcontrib><creatorcontrib>Luelmo, Jesús</creatorcontrib><title>Photodynamic therapy with intralesional methylene blue and a 635 nm light-emitting diode lamp in hidradenitis suppurativa: a retrospective follow-up study in 7 patients and a review of the literature</title><title>Photochemical &amp; photobiological sciences</title><addtitle>Photochem Photobiol Sci</addtitle><addtitle>Photochem Photobiol Sci</addtitle><description>Hidradenitis suppurativa is a chronic inflammatory skin disease which has an estimated prevalence of 1%. It is characterized by the formation of recurrent painful suppurative nodules and abscesses in the flexural areas of the body. It is believed that its pathogenesis involves an aberrant, genetically-determined activation of innate immunity against the bacterial commensal flora of intertriginous areas. It has been found that the formation of antibiotic-resistant bacterial biofilms is a common finding in hidradenitis lesions. Photodynamic therapy with different compounds and light sources has demonstrated its efficacy in a number of infectious diseases such as nail mycosis and chronic periodontitis. We retrospectively report our experience in the treatment of hidradenitis with photodynamic therapy using intralesional methylene blue and a 635 nm light-emitting diode lamp in 7 patients. Two patients received one session whereas 5 patients received two sessions. At one month follow-up good response was achieved in 6 patients. After 6 months, 5 patients (71%) maintained remission of the disease in the treated area. In view of the results and literature review, we regard methylene blue as an ideal photosensitizer for photodynamic therapy in this disease. Hidradenitis suppurativa is a chronic inflammatory skin disease which has an estimated prevalence 1%. It is characterized by the formation of recurrent painful suppurative nodules and abscesses in the flexural areas of the body.</description><subject>Adult</subject><subject>Aminolevulinic Acid - therapeutic use</subject><subject>Anti-Bacterial Agents - therapeutic use</subject><subject>Biochemistry</subject><subject>Biomaterials</subject><subject>Chemistry</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Hidradenitis Suppurativa - diagnostic imaging</subject><subject>Hidradenitis Suppurativa - drug therapy</subject><subject>Humans</subject><subject>Light</subject><subject>Longitudinal Studies</subject><subject>Male</subject><subject>Methylene Blue - therapeutic use</subject><subject>Middle Aged</subject><subject>Photochemotherapy</subject><subject>Photosensitizing Agents - therapeutic use</subject><subject>Physical Chemistry</subject><subject>Plant Sciences</subject><subject>Retrospective Studies</subject><subject>Treatment Outcome</subject><subject>Ultrasonography</subject><subject>Young Adult</subject><issn>1474-905X</issn><issn>1474-9092</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><recordid>eNqNkU2P1DAMhisEYj_gwh2UIwIVkkzapntDKxaQVoIDSNyqNHGmWaVJSNId9Rfyt8hohoEDB0627MevLb9V9YzgNwRv-reyDQFjzOn2QXVOWMfqHvf04Slvvp9VFyndYUwa1naPqzPaMdI1LT-vfn6ZfPZqdWI2EuUJoggr2pk8IeNyFBaS8U5YNEOeVgsO0GgXQMIpJFC7aZCbkTXbKdcwm5yN2yJlvAJkxRyKBpqMikKBM9kklJYQliiyuRdXZT5Cjj4FkKUASHtr_a5eAkp5Uet-uEOhwOByOm6McG9gh7ze31oW53JwXiI8qR5pYRM8PcbL6tvN-6_XH-vbzx8-Xb-7rWVD21z3rGWC6q7DTQOiF43utRyVZiCZ0uU7XHWckpEApz1mrSaiYSNrJaGUSdlvLquXB90Q_Y8FUh5mkyRYKxz4JQ2EE8I5JpT_B4p5i1vakYK-OqCyvCNF0EOIZhZxHQge9h4Pfzwu8Iuj7jLOoE7ob1ML8PoApNJyW4jDnV9iMTH9W-75gY5JnrT-6v8C-ju-0A</recordid><startdate>20160101</startdate><enddate>20160101</enddate><creator>Agut-Busquet, Eugènia</creator><creator>Romaní, Jorge</creator><creator>Gilaberte, Yolanda</creator><creator>García-Malinis, Ana</creator><creator>Ribera-Pibernat, Miquel</creator><creator>Luelmo, Jesús</creator><general>Springer International Publishing</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7QO</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope></search><sort><creationdate>20160101</creationdate><title>Photodynamic therapy with intralesional methylene blue and a 635 nm light-emitting diode lamp in hidradenitis suppurativa: a retrospective follow-up study in 7 patients and a review of the literature</title><author>Agut-Busquet, Eugènia ; Romaní, Jorge ; Gilaberte, Yolanda ; García-Malinis, Ana ; Ribera-Pibernat, Miquel ; Luelmo, Jesús</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c526t-9464a2f77055ea9a5f9fcbdf4ec4df5468d7821b1e829046f1a54b46c1224cc93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Adult</topic><topic>Aminolevulinic Acid - therapeutic use</topic><topic>Anti-Bacterial Agents - therapeutic use</topic><topic>Biochemistry</topic><topic>Biomaterials</topic><topic>Chemistry</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Hidradenitis Suppurativa - diagnostic imaging</topic><topic>Hidradenitis Suppurativa - drug therapy</topic><topic>Humans</topic><topic>Light</topic><topic>Longitudinal Studies</topic><topic>Male</topic><topic>Methylene Blue - therapeutic use</topic><topic>Middle Aged</topic><topic>Photochemotherapy</topic><topic>Photosensitizing Agents - therapeutic use</topic><topic>Physical Chemistry</topic><topic>Plant Sciences</topic><topic>Retrospective Studies</topic><topic>Treatment Outcome</topic><topic>Ultrasonography</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Agut-Busquet, Eugènia</creatorcontrib><creatorcontrib>Romaní, Jorge</creatorcontrib><creatorcontrib>Gilaberte, Yolanda</creatorcontrib><creatorcontrib>García-Malinis, Ana</creatorcontrib><creatorcontrib>Ribera-Pibernat, Miquel</creatorcontrib><creatorcontrib>Luelmo, Jesús</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Biotechnology Research Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><jtitle>Photochemical &amp; photobiological sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Agut-Busquet, Eugènia</au><au>Romaní, Jorge</au><au>Gilaberte, Yolanda</au><au>García-Malinis, Ana</au><au>Ribera-Pibernat, Miquel</au><au>Luelmo, Jesús</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Photodynamic therapy with intralesional methylene blue and a 635 nm light-emitting diode lamp in hidradenitis suppurativa: a retrospective follow-up study in 7 patients and a review of the literature</atitle><jtitle>Photochemical &amp; photobiological sciences</jtitle><stitle>Photochem Photobiol Sci</stitle><addtitle>Photochem Photobiol Sci</addtitle><date>2016-01-01</date><risdate>2016</risdate><volume>15</volume><issue>8</issue><spage>12</spage><epage>128</epage><pages>12-128</pages><issn>1474-905X</issn><eissn>1474-9092</eissn><abstract>Hidradenitis suppurativa is a chronic inflammatory skin disease which has an estimated prevalence of 1%. It is characterized by the formation of recurrent painful suppurative nodules and abscesses in the flexural areas of the body. It is believed that its pathogenesis involves an aberrant, genetically-determined activation of innate immunity against the bacterial commensal flora of intertriginous areas. It has been found that the formation of antibiotic-resistant bacterial biofilms is a common finding in hidradenitis lesions. Photodynamic therapy with different compounds and light sources has demonstrated its efficacy in a number of infectious diseases such as nail mycosis and chronic periodontitis. We retrospectively report our experience in the treatment of hidradenitis with photodynamic therapy using intralesional methylene blue and a 635 nm light-emitting diode lamp in 7 patients. Two patients received one session whereas 5 patients received two sessions. At one month follow-up good response was achieved in 6 patients. After 6 months, 5 patients (71%) maintained remission of the disease in the treated area. In view of the results and literature review, we regard methylene blue as an ideal photosensitizer for photodynamic therapy in this disease. Hidradenitis suppurativa is a chronic inflammatory skin disease which has an estimated prevalence 1%. It is characterized by the formation of recurrent painful suppurative nodules and abscesses in the flexural areas of the body.</abstract><cop>Cham</cop><pub>Springer International Publishing</pub><pmid>27417568</pmid><doi>10.1039/c6pp00082g</doi><tpages>9</tpages></addata></record>
fulltext fulltext
identifier ISSN: 1474-905X
ispartof Photochemical & photobiological sciences, 2016-01, Vol.15 (8), p.12-128
issn 1474-905X
1474-9092
language eng
recordid cdi_rsc_primary_c6pp00082g
source Springer Nature:Jisc Collections:Springer Nature Read and Publish 2023-2025: Springer Reading List
subjects Adult
Aminolevulinic Acid - therapeutic use
Anti-Bacterial Agents - therapeutic use
Biochemistry
Biomaterials
Chemistry
Female
Follow-Up Studies
Hidradenitis Suppurativa - diagnostic imaging
Hidradenitis Suppurativa - drug therapy
Humans
Light
Longitudinal Studies
Male
Methylene Blue - therapeutic use
Middle Aged
Photochemotherapy
Photosensitizing Agents - therapeutic use
Physical Chemistry
Plant Sciences
Retrospective Studies
Treatment Outcome
Ultrasonography
Young Adult
title Photodynamic therapy with intralesional methylene blue and a 635 nm light-emitting diode lamp in hidradenitis suppurativa: a retrospective follow-up study in 7 patients and a review of the literature
url http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-25T02%3A21%3A14IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_rsc_p&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Photodynamic%20therapy%20with%20intralesional%20methylene%20blue%20and%20a%20635%20nm%20light-emitting%20diode%20lamp%20in%20hidradenitis%20suppurativa:%20a%20retrospective%20follow-up%20study%20in%207%20patients%20and%20a%20review%20of%20the%20literature&rft.jtitle=Photochemical%20&%20photobiological%20sciences&rft.au=Agut-Busquet,%20Eug%C3%A8nia&rft.date=2016-01-01&rft.volume=15&rft.issue=8&rft.spage=12&rft.epage=128&rft.pages=12-128&rft.issn=1474-905X&rft.eissn=1474-9092&rft_id=info:doi/10.1039/c6pp00082g&rft_dat=%3Cproquest_rsc_p%3E1811880128%3C/proquest_rsc_p%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c526t-9464a2f77055ea9a5f9fcbdf4ec4df5468d7821b1e829046f1a54b46c1224cc93%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=1808606271&rft_id=info:pmid/27417568&rfr_iscdi=true