A drug release switch based on protein-inhibitor supramolecular interaction

In this report, we describe a new system in which mesoporous silica nanoparticles (MSNs) are gated with α-chymotrypsin A protein (CTRA) and the cargoes within the vehicles are released in the presence of phenylmethanesulfonyl fluoride (PMSF), a canonical inhibitor of CTRA. This cargo release switch...

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Bibliographic Details
Published in:RSC advances 2016-01, Vol.6 (3), p.2548-25484
Main Authors: Wang, Xiaoliang, Liu, Pengchang, Chen, Zhijun, Shen, Jiacong
Format: Article
Language:English
Subjects:
Cargo
Complex formation
Drug delivery systems
Gating systems
Nanoparticles
Proteins
Switches
Vehicles
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Summary:In this report, we describe a new system in which mesoporous silica nanoparticles (MSNs) are gated with α-chymotrypsin A protein (CTRA) and the cargoes within the vehicles are released in the presence of phenylmethanesulfonyl fluoride (PMSF), a canonical inhibitor of CTRA. This cargo release switch is based on the specific interaction between CTRA and PMSF as well as structural changes upon their supramolecular complex formation. This host-guest gating system works smoothly both in vitro and within cells. This type of bio-switch may be extended to other drug carrier systems by using diverse protein-inhibitor pairs that exist in nature. The cargo release can be triggered by the specific interaction between the protein and its inhibitor.
ISSN:2046-2069
2046-2069
DOI:10.1039/c6ra03543d