Phosphorescent oxygen-sensing and singlet oxygen production by a biosynthetic silk

A recombinant coiled-coil silk was utilised to immobilise heavy-metal-macrocycles which are known to undergo efficient intersystem crossing from the singlet state to the triplet state following excitation with visible light. This spin-forbidden transition leads to phosphorescence and the production...

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Bibliographic Details
Published in:RSC advances 2016-01, Vol.6 (46), p.3953-39533
Main Authors: Horgan, Conor C, Han, Yong-Shen, Trueman, Holly, Jackson, Colin J, Sutherland, Tara D, Rapson, Trevor D
Format: Article
Language:English
Subjects:
Binding
Biomedical materials
Coiling
Phosphorescence
Photochemical
Photodynamic therapy
Recombinant
Silk
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Summary:A recombinant coiled-coil silk was utilised to immobilise heavy-metal-macrocycles which are known to undergo efficient intersystem crossing from the singlet state to the triplet state following excitation with visible light. This spin-forbidden transition leads to phosphorescence and the production of cytotoxic oxygen species. We explore the requirements for specific binding of these macrocycles and demonstrate that immobilisation does not adversely affect their photochemical properties. The biocompatible materials developed here have potential biomedical applications in photodynamic therapy (PDT) and dynamic oxygen-sensing. A recombinant coiled-coil silk was utilised to immobilise heavy-metal-macrocycles which are known to undergo efficient intersystem crossing from the singlet state to the triplet state following excitation with visible light.
ISSN:2046-2069
2046-2069
DOI:10.1039/c6ra03731c