Markovnikov addition of imidazole derivatives with vinyl esters catalyzed by lipase TL IM from /KCO in a continuous-flow microreactor

In this work, a simple and efficient method for Markovnikov addition of imidazole derivatives to vinyl esters catalyzed by Lipozyme TL IM/K 2 CO 3 in a continuous-flow microreactor was described. The effects of the mixed catalysts, molar ratio and the structure of reactants on the reaction performan...

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Bibliographic Details
Published in:RSC advances 2016-06, Vol.6 (64), p.591-5913
Main Authors: Du, Li-Hua, Cheng, Bing-Zhuo, Yang, Wen-Jun, Xu, Liang-Liang, Luo, Xi-Ping
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Summary:In this work, a simple and efficient method for Markovnikov addition of imidazole derivatives to vinyl esters catalyzed by Lipozyme TL IM/K 2 CO 3 in a continuous-flow microreactor was described. The effects of the mixed catalysts, molar ratio and the structure of reactants on the reaction performance were experimentally studied. The attractive features of this process are shorter reaction times (30 min) and excellent yields compared to that in shaker reactors. In this work, a simple and efficient method for Markovnikov addition of imidazole derivatives to vinyl esters catalyzed by Lipozyme TL IM/K 2 CO 3 in a continuous-flow microreactor was described.
ISSN:2046-2069
DOI:10.1039/c6ra05983j