Functionalization of pyridyl ketones using deprotolithiation-in situ zincationElectronic supplementary information (ESI) available: General procedures, experimental procedures and compound characterizations, 1H and 13C NMR spectra of the new compounds, and X-ray crystallographic data. CCDC 1475309 (2j′), 1475009 (2k′) and 1475010 (2n′). For ESI and crystallographic data in CIF or other electronic format see DOI: 10.1039/c6ra11370b

The metallation of aryl ketones was achieved by using LiTMP in the presence of ZnCl 2 ·TMEDA, as evidenced by subsequent interception with iodine or by a palladium-catalysed cross-coupling reaction. One of the synthesized iodo ketones has been further elaborated to reach derivatives of biological in...

Full description

Saved in:
Bibliographic Details
Main Authors: Hedidi, Madani, Erb, William, Lassagne, Frédéric, Halauko, Yury S, Ivashkevich, Oleg A, Matulis, Vadim E, Roisnel, Thierry, Bentabed-Ababsa, Ghenia, Mongin, Florence
Format: Article
Language:English
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The metallation of aryl ketones was achieved by using LiTMP in the presence of ZnCl 2 ·TMEDA, as evidenced by subsequent interception with iodine or by a palladium-catalysed cross-coupling reaction. One of the synthesized iodo ketones has been further elaborated to reach derivatives of biological interest. Metallation of aryl ketones was achieved by using LiTMP in the presence of ZnCl 2 ·TMEDA, as evidenced by subsequent interception with iodine or by palladium-catalysed cross-coupling reaction.
ISSN:2046-2069
DOI:10.1039/c6ra11370b