Interactive luminescent gold nanocluster embedded dsDNA and cisplatin as model nanoparticles for cancer theranosticsAn Indian patent application has been filed and international patent filing is under consideration. This is related to the method of synthesis of gold nanoclusters on dsDNA using a single PCR based heating and cooling cycle.Electronic supplementary information (ESI) available: Detailed experimental procedure, size distribution, UV-vis absorption spectrum, quantum yield calculation,

Plasmid DNA embedded with luminescent gold nanoclusters were reacted with cisplatin to form composite nanoparticles (composite NPs) for theranostic applications. The composite NPs delivered the cisplatin to cervical cancer HeLa cells in vitro , inducing apoptosis mediated cell death. The luminescent...

Full description

Saved in:
Bibliographic Details
Main Authors: Chatterjee, Bandhan, Sahoo, Amaresh Kumar, Ghosh, Siddhartha Sankar, Chattopadhyay, Arun
Format: Article
Language:English
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Plasmid DNA embedded with luminescent gold nanoclusters were reacted with cisplatin to form composite nanoparticles (composite NPs) for theranostic applications. The composite NPs delivered the cisplatin to cervical cancer HeLa cells in vitro , inducing apoptosis mediated cell death. The luminescent gold nanoclusters were simultaneously used for cellular imaging. Luminescent gold nanoclusters in DNA and cisplatin produced nanoparticle for theranostics.
ISSN:2046-2069
DOI:10.1039/c6ra24325h