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In vivo endoscopic mass spectrometry using a moving string sampling probeElectronic supplementary information (ESI) available. See DOI: 10.1039/c7an00650k
At present, endoscopy relies almost exclusively on optical microscopy and the accurate analysis such as MS interrogation is performed ex situ using biopsy. In this work, a novel probing system is developed to perform in situ and in vivo endoscopic mass spectrometry using a moving string for the samp...
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Main Authors: | , , , , , , , |
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Format: | Article |
Language: | English |
Online Access: | Get full text |
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Summary: | At present, endoscopy relies almost exclusively on optical microscopy and the accurate analysis such as MS interrogation is performed
ex situ
using biopsy. In this work, a novel probing system is developed to perform
in situ
and
in vivo
endoscopic mass spectrometry using a moving string for the sampling and transportation of material. A prototype of a mass spectrometric endoscope is constructed using an industrial endoscope and a commercial mass spectrometer. The sampling system consists of a moving cotton thread driven by motorized pulleys. When the target surface is touched by the sampling probe, the cotton thread "wipes" and transports the adhered sample to the ion source. Depending on the target analytes, desorption electrospray and atmospheric pressure chemical ionization sources are employed interchangeably for the desorption and ionization. The surface under analysis is not subjected to heat, organic solvents, high voltage or charged droplets.
In situ
endoscopic MS of a living mouse and surface analysis inside a volunteer subject's mouth are demonstrated.
A novel moving string sampling probe and sample transportation system for performing
in situ
and
in vivo
endoscopic MS. |
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ISSN: | 0003-2654 1364-5528 |
DOI: | 10.1039/c7an00650k |