Peptide array functionalization via the Ugi four-component reactionElectronic supplementary information (ESI) available: Detailed experimental procedures, additional fluorescence measurements and MALDI-ToF results. See DOI: 10.1039/c7cc01945a

The Ugi four-component reaction was investigated as a tool for the functionalization of peptide arrays via post-synthetic side-chain modification, mimicking post-translational processes. Additionally, as a proof of concept for the synthesis of peptidomimetics on arrays, the integration of an Ugi uni...

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Main Authors: Ridder, B, Mattes, D. S, Nesterov-Mueller, A, Breitling, F, Meier, M. A. R
Format: Article
Language:English
Online Access:Get full text
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Summary:The Ugi four-component reaction was investigated as a tool for the functionalization of peptide arrays via post-synthetic side-chain modification, mimicking post-translational processes. Additionally, as a proof of concept for the synthesis of peptidomimetics on arrays, the integration of an Ugi unit into a growing peptide chain was demonstrated. The Ugi four-component reaction was investigated as a tool for the functionalization of peptide arrays via post-synthetic side-chain modification as well as integration of an Ugi unit into a growing peptide chain.
ISSN:1359-7345
1364-548X
DOI:10.1039/c7cc01945a