Lanthanoplatins: emissive Eu(iii) and Tb(iii) complexes staining nucleoli targeted through Pt-DNA crosslinkingElectronic supplementary information (ESI) available: Experimental, methods, characterization details, and cellular imaging data. See DOI: 10.1039/c7cc02047c

Two highly luminescent water-soluble heterometallic LnPt 2 complexes, [{ cis -PtCl(NH 3 ) 2 } 2 Ln(L)(H 2 O)](NO 3 ) 2 (Ln = Eu (1), Tb (2)), have been designed for their selective nucleoli staining through formation of Pt-DNA crosslinks. The complexes showed significant cellular uptake and distinct...

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Main Authors: Singh, Khushbu, Singh, Swati, Srivastava, Payal, Sivakumar, Sri, Patra, Ashis K
Format: Article
Language:English
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Summary:Two highly luminescent water-soluble heterometallic LnPt 2 complexes, [{ cis -PtCl(NH 3 ) 2 } 2 Ln(L)(H 2 O)](NO 3 ) 2 (Ln = Eu (1), Tb (2)), have been designed for their selective nucleoli staining through formation of Pt-DNA crosslinks. The complexes showed significant cellular uptake and distinctive nucleoli localization through intrinsic emission from Eu III or Tb III observed through confocal fluorescence microscopy. Luminescent photostable heterometallic LnPt 2 complexes were designed for their preferential nucleoli staining through formation of Pt-DNA cross-links observed through fluorescence microscopy.
ISSN:1359-7345
1364-548X
DOI:10.1039/c7cc02047c