An esterase-activated click and release approach to metal-free CO-prodrugsElectronic supplementary information (ESI) available. See DOI: 10.1039/c7cc03832a

One major challenge in the development of CO as a therapeutic agent is its controllable delivery in a pharmaceutically acceptable form. Herein, we describe for the first time a general chemical strategy to esterase-sensitive organic CO-prodrugs. Metal-free CO prodrugs with a biological trigger and t...

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Bibliographic Details
Main Authors: Ji, Xingyue, Ji, Kaili, Chittavong, Vayou, Yu, Bingchen, Pan, Zhixiang, Wang, Binghe
Format: Article
Language:English
Online Access:Get full text
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Summary:One major challenge in the development of CO as a therapeutic agent is its controllable delivery in a pharmaceutically acceptable form. Herein, we describe for the first time a general chemical strategy to esterase-sensitive organic CO-prodrugs. Metal-free CO prodrugs with a biological trigger and tunable release rate are described herein for the first time.
ISSN:1359-7345
1364-548X
DOI:10.1039/c7cc03832a