A DNA nanoribbon as a potent inhibitor of metallo-β-lactamasesElectronic supplementary information (ESI) available. See DOI: 10.1039/c7cc04483f

We discovered a promising metallo-β-lactamase inhibitor, a DNA nanoribbon, by enzymatic kinetics and isothermal titration calorimetry evaluations. Atomic force microscopy, gel electrophoresis, competitive binding experiments, circular dichroic and thermal denaturation studies suggested that the DNA...

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Main Authors: Ouyang, Xiangyuan, Chang, Ya-Nan, Yang, Ke-Wu, Wang, Wen-Ming, Bai, Jian-Jian, Wang, Jian-Wei, Zhang, Yue-Juan, Wang, Si-Yao, Xie, Bin-Bin, Wang, Li-Li
Format: Article
Language:English
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Summary:We discovered a promising metallo-β-lactamase inhibitor, a DNA nanoribbon, by enzymatic kinetics and isothermal titration calorimetry evaluations. Atomic force microscopy, gel electrophoresis, competitive binding experiments, circular dichroic and thermal denaturation studies suggested that the DNA nanoribbon could bind to the enzyme through a minor groove. A DNA nanoribbon has been discovered that inhibits the activity of metallo-β-lactamases by binding to the enzyme.
ISSN:1359-7345
1364-548X
DOI:10.1039/c7cc04483f