Fluorous photosensitizers enhance photodynamic therapy with perfluorocarbon nanoemulsions

Photodynamic therapy (PDT) requires a photosensitizer, light, and oxygen to induce cell death. The majority of efforts to advance PDT focus only on the first two components. Here, we employ perfluorocarbon nanoemulsions to simultaneously deliver oxygen and a photosensitizer. We find that the impleme...

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Bibliographic Details
Published in:Chemical communications (Cambridge, England) England), 2017-12, Vol.53 (97), p.1343-1346
Main Authors: Day, Rachael A, Estabrook, Daniel A, Logan, Jessica K, Sletten, Ellen M
Format: Article
Language:English
Subjects:
Cell death
Nanoemulsions
Perfluorocarbons
Photodynamic therapy
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Summary:Photodynamic therapy (PDT) requires a photosensitizer, light, and oxygen to induce cell death. The majority of efforts to advance PDT focus only on the first two components. Here, we employ perfluorocarbon nanoemulsions to simultaneously deliver oxygen and a photosensitizer. We find that the implementation of fluorous soluble photosensitizers enhances the efficacy of PDT. Photodynamic therapy (PDT) requires a photosensitizer, light and oxygen to induce cell death. Here, we simultaneously deliver oxygen and photosensitizer using perfluorocarbon nanoemulsions.
ISSN:1359-7345
1364-548X
DOI:10.1039/c7cc07038a