Visible-light-mediated cleavage of polymer chains under physiological conditions quinone photoreduction and trimethyl lock

We introduce a click and visible-light triggered unclick approach via thio-bromo reaction and hydroquinone photoreduction/trimethyl lock cleavage for polymer modifications. Both reactions can be carried out in water and at ambient temperature, enabling preparation of bioorthogonal hydrogels for enca...

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Published in:Chemical communications (Cambridge, England) England), 2017-11, Vol.53 (89), p.1276-1279
Main Authors: Truong, Vinh X, Li, Fanyi, Ercole, Francesca, Forsythe, John S
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Summary:We introduce a click and visible-light triggered unclick approach via thio-bromo reaction and hydroquinone photoreduction/trimethyl lock cleavage for polymer modifications. Both reactions can be carried out in water and at ambient temperature, enabling preparation of bioorthogonal hydrogels for encapsulation and controlled release of various cells. We introduce a click and visible-light triggered unclick approach via thio-bromo reaction and hydroquinone photoreduction/trimethyl lock cleavage for polymer modifications.
ISSN:1359-7345
1364-548X
DOI:10.1039/c7cc07257k